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Year : 2018  |  Volume : 11  |  Issue : 3  |  Page : 132-135
Mondor’s disease after aesthetic breast surgery: A case series and literature review

1 Clinica Goldman and Hospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brazil
2 Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany

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Date of Web Publication9-Nov-2018


Background: Mondor’s disease of the subcutaneous veins of the breast is an uncommon disorder. The etiology of Mondor’s disease remains unclear. Usually, it is a self-limited disease. This condition has been associated with trauma, surgical biopsies, breast surgery (including silicone breast implant), physical activity, and a manifestation of breast cancer. Materials and Methods: This is a retrospective analysis of 652 female patients who underwent aesthetic breast surgery in the last 10 years. Results: We found three cases of Mondor’s disease after plastic surgery of the breast (0.46%) and performed an analysis of the clinical aspects and therapeutic measures. The disease onset was a couple of weeks to 2 years after surgery, never within the first 2 weeks after surgery. We did not observe ulceration or breast cancer. Treatment was unnecessary in two patients, whereas hot compresses and nonsteroidal medical drugs were prescribed in one patient. All lesions healed within 2–3 weeks. Conclusion: Mondor’s disease is a possible complication after aesthetic breast surgery but often runs a self-limiting course with spontaneous remission. It is important to exclude breast cancer. The patient should be informed that the disease runs a benign and self-limiting course.

Keywords: Mammoplasty, Mondor’s disease, silicone implant, superficial thrombophlebitis

How to cite this article:
Goldman A, Wollina U. Mondor’s disease after aesthetic breast surgery: A case series and literature review. J Cutan Aesthet Surg 2018;11:132-5

How to cite this URL:
Goldman A, Wollina U. Mondor’s disease after aesthetic breast surgery: A case series and literature review. J Cutan Aesthet Surg [serial online] 2018 [cited 2022 Oct 7];11:132-5. Available from:

   Introduction Top

Superficial vein thrombosis and thrombophlebitis were initially described by Mondor[1] in 1939 in the subcutaneous veins of the anterolateral thoracoabdominal wall. Mondor’s disease commonly affects the vessels of the lateral thoracic, thoracoepigastric, and superior epigastric veins. The involvement of upper arms, abdomen, groin, or penis is less common.[2]

The concept of Mondor’s disease has been further developed and now also includes subcutaneous thrombosis of the dorsal vein of the penis and retractile scarring of the fascia after breast surgery without concomitant superficial vein thrombosis.[3]

The pathogenesis is not completely understood. The initial event may be a trauma, surgery, medical drug therapy, or hypercoagulability. The possible role of cancer has been debated as cancer can cause thrombotic events.[4]

The sudden onset may scare patients. They may feel a strain or a painful induration under the skin, but the disease can also be asymptomatic. One can see and palpate a cord-like induration of affected veins. Doppler ultrasound examination allows confirmation of the disease in the form of a superficially located, longitudinal, anechoic lesion such as rosary beads without blood flow.[5]

In case of biopsy, immunohistochemical staining for CD31 and D240 is considered as reliable to distinguish small veins from lymphatic vessels. Differential diagnoses include (sclerosing) lymphangitis, lymphangiosis carcinomatosa, mastodynia, and penile fracture, depending on the affected sites.[6]

Usually, Mondor’s disease is a benign, self-limiting condition with spontaneous resolution. Nonsteroidal anti-inflammatory drugs, anticoagulation therapy, and even surgery have been used for its treatment as necessary.[3],[7] Successful triamcinolone injections have been reported recently.[8]

   Case Reports Top

We report a retrospective analysis of 652 female patients who underwent aesthetic breast surgery within the last 10 years. Mondor’s disease was confirmed by the Doppler ultrasound. Three cases aged 52, 34, and 38 years (0.46%) could be identified, who developed Mondor’s disease after breast surgery. None of these patients had hypercoagulability, trauma (except surgery), or breast cancer.

Case report 1

A 52-year-old woman with breast ptosis and hypertrophy underwent bilateral breast reduction. The procedure was performed under general anesthesia. The postoperative period was entirely uneventful until 9 weeks later, when she presented with longitudinal fibrous strings in the lateral thoracic vessels (under the left breast) and also in the abdominal wall. No pain or other symptoms were reported. The clinical diagnosis was superficial thrombophlebitis (Mondor’s disease) following breast surgery. The fibrous cord disappeared spontaneously 3 weeks later [Figure 1]A and B].
Figure 1: (A) Longitudinal fibrous strings after breast reduction. (B) The same patient with Mondor’s disease of the abdominal wall

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Case report 2

A 34-year-old woman presented with Mondor’s thrombophlebitis 2 years after augmentation mammoplasty. She did not report any problem after the surgery and remained asymptomatic for 2 years. She reported that after an exhaustive physical activity, a painful fibrous and hard cord tumor in the left side of the thoracoabdominal wall was observed. The physical examination showed a normal breast, without contracture and a good quality periareolar scar. Ultrasonography, magnetic resonance imaging, and mammography were normal. The diagnosis was Mondor’s disease. We prescribed warm compresses and nonsteroidal anti-inflammatory drugs. The symptoms disappeared in 2 weeks [Figure 2]A and B].
Figure 2: (A) Mondor’s thrombophlebitis 2 years after augmentation mammoplasty. (B) The same patient 2 weeks after clinical treatment

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Case report 3

A 38-year-old woman was admitted to obtain a bilateral retroglandular silicone breast implant via inframammary fold. The postoperative period was uneventful until the 3rd week. The patient observed a fibrous cord below the right breast without any other symptoms. The clinical diagnosis was thrombophlebitis of the subcutaneous vein as a symptom of Mondor’s disease. The cord-like lesions disappeared 2 weeks later without any treatment [Figure 3].
Figure 3: Mondor’s disease presenting as a fibrous cord below the right breast 3 weeks after silicone breast implant

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   Discussion Top

Mondor’s disease is a benign, self-limited vascular disease. Approximately 75% of the patients are women. The incidence of Mondor’s disease among the female patients with breast disorders is between 0.5% and 0.8%.[9]

Trauma to the breast can cause Mondor’s disease. In the literature, ultrasound-guided core biopsy, mammotome biopsy, mastopexy with breast augmentation, breast reduction surgery, and tight bra, but also due to gigantomastia.[10],[11],[12],[13],[14],[15],[16],[17],[18] It is important to exclude breast cancer in such cases.[9],[19],[20]

In our case series of 652 women, breast surgery was the trigger for postoperative Mondor’s disease in 0.46% of patients. The largest series has been reported from France with eight patients. The authors suggested that Mondor’s disease is caused in this setting by fascial changes.[21] An Italian group reported three cases after implant-based breast reconstruction in nonobese, nonsmoking patients without hypercoagulability of thrombotic risks.[12] Another three cases have been reported after subfascial breast augmentation.[13] We observed a delay of several weeks between surgery and the onset of symptoms. Sometimes the delay between surgery and Mondor’s disease can be as long as 13 years.[22] On the other hand, there is neither a close relationship between Mondor’s disease and silicone breast implants nor between Mondor’s disease and capsule contracture.[23]

In two of our three patients, no treatment was warranted. The third patient was treated by nonsteroidal drugs and warm compresses. The lesions disappeared within 2–3 weeks without leaving any footprints. However, secondary ulcerations may rarely occur as a complication.[24]

   Conclusion Top

Mondor’s disease is a rare but possible complication after aesthetic breast surgery. Although disconcerting for the patient, the disease is benign and self-limiting. Treatment is not always necessary, and in most of such cases, nonsteroidal anti-inflammatory drugs are the first choice.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

   References Top

Mondor H. Tronculite sous-cutanee subaigue de la panoi thoracique antero-laterale. Mem Acad Chir 1939;11:1271-8.  Back to cited text no. 1
Alvarez-Garrido H, Garrido-Ríos AA, Sanz-Muñoz C, Miranda-Romero A. Mondor’s disease. Clin Exp Dermatol 2009;11:753-6.  Back to cited text no. 2
Laroche JP, Galanaud J, Labau D, Van Kien AK, Brisot D, Boge G, et al. Mondor’s disease: what’s new since 1939? Thromb Res 2012;11:S56-8.  Back to cited text no. 3
Shirah BH, Shirah HA, Alonazie WS. The effectiveness of diclofenac sodium in the treatment of Mondor’s disease of the breast: the topical patch compared to the oral capsules. Breast J 2017;11:395-400.  Back to cited text no. 4
Shah NA, Gryskiewicz J, Crutchfield CE 3rd. Successful treatment of a recalcitrant Mondor’s cord following breast augmentation. J Clin Aesthet Dermatol 2014;11:50-1.  Back to cited text no. 5
Salemis NS, Merkouris S, Kimpouri K. Mondor’s disease of the breast. A retrospective review. Breast Dis 2011;11:103-7.  Back to cited text no. 6
O’Neal JM, Castleberg E, Dinh VA. Diagnosis of Mondor’s disease in the emergency department with bedside ultrasound. Case Rep Emerg Med 2015;11:817960.  Back to cited text no. 7
Alvarez-Garrido H, Sanz-Muñoz C, Pericet-Fernández L, Garrido-Ríos AA, Miranda-Romero A. Immunohistochemical clues to the diagnosis of Mondor’s disease of the penis. Clin Exp Dermatol 2009;11:e663-5.  Back to cited text no. 8
Pasta V, D’Orazi V, Sottile D, Del Vecchio L, Panunzi A, Urciuoli P. Breast Mondor’s disease: diagnosis and management of six new cases of this underestimated pathology. Phlebology 2015;11:564-8.  Back to cited text no. 9
Salemis NS, Vasilara G, Lagoudianakis E. Mondor’s disease of the breast as a complication of ultrasound-guided core needle biopsy: management and review of the literature. Breast Dis 2015;11:73-6.  Back to cited text no. 10
Kibil W, Hodorowicz-Zaniewska D, Kulig J. Mondor’s disease in a patient after a mammotome biopsy. Wideochir Inne Tech Maloinwazyjne 2015;11:138-40.  Back to cited text no. 11
Pignatti M, Loschi P, Pedrazzi P, Marietta M. Mondor’s disease after implant-based breast reconstruction. Report of three cases and review of the literature. J Plast Reconstr Aesthet Surg 2014;11:e275-7.  Back to cited text no. 12
Tijerina VN, Saenz RA. Mondor’s syndrome: a clinical finding on subfascial breast augmentation. Aesthetic Plast Surg 2010;11:531-3.  Back to cited text no. 13
Marín-Bertolín S, González-Martínez R, Velasco-Pastor M, Gil-Mateo MD, Amorrortu-Velayos J. Mondor’s disease and aesthetic breast surgery: report of case secondary to mastopexy with augmentation. Aesthetic Plast Surg 1995;11:251-2.  Back to cited text no. 14
Loos B, Horch RE. Mondor’s disease after breast reduction surgery. Plast Reconstr Surg 2006;11:129e-32e.  Back to cited text no. 15
Thiery G, Liard O, Duboscq JC. [Mondor’s disease: about two cases]. Ann Chir Plast Esthet 2005;11:251-4.  Back to cited text no. 16
Vincenza Polito M, De Cicco P, Apicella R. Tight bra in a 34-year-old woman: an unusual cause of Mondor’s disease. Ann Vasc Dis 2014;11:149-51.  Back to cited text no. 17
Pasta V, Redler A, Giofrè M, Merola R, Monti M. Observations and considerations on a case of Mondor’s syndrome associated with gigantomastia. Ann Ital Chir 2011;11:481-5.  Back to cited text no. 18
Catania S, Zurrida S, Veronesi P, Galimberti V, Bono A, Pluchinotta A. Mondor’s disease and breast cancer. Cancer 1992;11:2267-70.  Back to cited text no. 19
Markopoulos C, Kouskos E, Mantas D, Kakisis J, Antonopoulou Z, Kontzoglou K, et al. Mondor’s disease of the breast: is there any relation to breast cancer? Eur J Gynaecol Oncol 2005;11:213-4.  Back to cited text no. 20
Lhoest F, Grandjean FX, Heymans O. [Mondor’s disease: a complication after breast surgery]. Ann Chir Plast Esthet 2005;11:197-201.  Back to cited text no. 21
Coscia J, Lance S, Wong M, Garcia J. Mondor’s thrombophlebitis 13 years after breast augmentation. Ann Plast Surg 2012;11:336-7.  Back to cited text no. 22
Green RA, Dowden RV. Mondor’s disease in plastic surgery patients. Ann Plast Surg 1988;11:231-5.  Back to cited text no. 23
Shousha S, Chun J. Ulcerated Mondor’s disease of the breast. Histopathology 2008;11:395-6.  Back to cited text no. 24

Correspondence Address:
Uwe Wollina
Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University of Dresden, Friedrichstrasse 41, 01067 Dresden
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JCAS.JCAS_69_18

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