Journal of Cutaneous and Aesthetic Surgery
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Year : 2011  |  Volume : 4  |  Issue : 2  |  Page : 111-117

Maspin expression in epithelial skin tumours: An immunohistochemical study

1 Department of Pathology, Faculty of Medicine, Menofiya University, Shebein El kom, Egypt
2 Department of Dermatology and Andrology, Faculty of Medicine, Menofiya University, Shebein El kom, Egypt

Correspondence Address:
Asmaa Gaber Abdou
Department of Pathology, Faculty of Medicine, Menofiya University, Shebein El kom
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-2077.85028

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Background: Maspin is a member of the serpin family of protease inhibitors and is thought to inhibit carcinoma invasion, metastasis, angiogenesis and induce apoptosis. Aim: The aim of this work is to investigate maspin expression in cutaneous basal and squamous cell carcinomas by means of immunohistochemistry. Materials and Methods: This study was carried out on 43 patients, 25 basal cell carcinoma (BCC) and 18 squamous cell carcinoma (SCC) together with ten apparently healthy volunteers as a control group. Results: There was a significant difference between the malignant and control groups regarding maspin expression since all control cases showed maspin expression compared to 60.5% (26/43) positivity in malignant cases. Maspin positive expression tended to be of higher percentage in SCC (77.8%) compared to BCC (48%) (P = 0.06) and the strong intensity of maspin was also significantly in favour of SCC compared to BCC (P = 0.02). The staining of both the cytoplasm and nuclei was seen in 27.7% of SCC and 12% of BCC and was significantly in favour of older age group (P = 0.02) and the adenoid variant (P = 0.04) of the latter. Conclusions: Maspin is associated with terminal squamous differentiation. Nuclear staining of maspin is seen in both BCC and SCC with a suggested tumour suppressor role in BCC.

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