Journal of Cutaneous and Aesthetic Surgery
Print this page
Email this page
Small font size
Default font size
Increase font size
Home About us Current issue Archives Instructions Submission Subscribe Editorial Board Partners Contact e-Alerts Login 

SHORT COMMUNICATION Table of Contents   
Year : 2009  |  Volume : 2  |  Issue : 2  |  Page : 104-106
The efficacy of silicone gel for the treatment of hypertrophic scars and keloids

Department of Dermatology, Guru Gobind Singh Medical College, Faridkot, Punjab, India

Click here for correspondence address and email

Date of Web Publication24-Dec-2009


Topical self drying silicone gel is a relatively recent treatment modality promoted as an alternative to topical silicone gel sheeting. Thirty patients with scars of different types including superficial scars, hypertrophic scars, and keloids were treated with silicon gel application. The results of the self-drying silicone gel have been satisfactory.

Keywords: Keloids, scars, silicone

How to cite this article:
Puri N, Talwar A. The efficacy of silicone gel for the treatment of hypertrophic scars and keloids. J Cutan Aesthet Surg 2009;2:104-6

How to cite this URL:
Puri N, Talwar A. The efficacy of silicone gel for the treatment of hypertrophic scars and keloids. J Cutan Aesthet Surg [serial online] 2009 [cited 2021 Dec 8];2:104-6. Available from:

   Introduction Top

Scars vary greatly in quality, depending on individual and racial patient features, the nature of the trauma, and the conditions of wound healing. [1] They frequently determine aesthetic impairment and may be symptomatic, causing itching, tenderness, pain, sleep disturbance, anxiety, depression and disruption of daily activities. Other psychological sequelae include posttraumatic stress reactions, loss of self esteem and stigmatization leading to a diminished quality of life. Scar contractures also can determine disabling physical deformities. [2],[3],[4],[5] All these problems are more troublesome to the individual patient, particularly when the scar cannot be hidden by clothes. This study was undertaken to verify the efficacy of a new topical silicone treatment; a self-drying spreadable gel that needs no means of fixation and cannot be seen because of complete transparency.

Silicone gel contains long chain silicone polymer (polysiloxanes), silicone dioxide and volatile component. Long chain silicone polymers cross link with silicone dioxide. It spreads as an ultra thin sheet and works 24 hours per day. [6],[7] It has a self drying technology and itself dries within 4-5 minutes. It has been reported to be effective and produce 86% reduction in texture, 84% in color and 68% in height of scars. [8],[9] Silicon gel exerts several actions which may explain this benefit in scars:

  1. It increases hydration of stratum corneum and thereby facilitates regulation of fibroblast production and reduction in collagen production. It results into softer and flatter scar. It allows skin to "breathe".
  2. It protects the scarred tissue from bacterial invasion and prevents bacteria- induced excessive collagen production in the scar tissue.
  3. It modulates the expression of growth factors, fibroblast growth factor β (FGF β) and tumor growth factor β (TGF β). TGF β stimulates fibroblasts to synthesize collagen and fibronectin. FGF β normalizes the collagen synthesis in an abnormal scar and increases the level of collagenases which breaks down the excess collagen. Balance of fibrogenesis and fibrolysis is ultimately restored.
  4. Silicone gel reduces itching and discomfort associated with scars.

The advantages of silicon gel include easy administration, even for sensitive skin and in children. It can be applied for any irregular skin or scar surfaces, the face, moving parts (joints and flexures) and any size of scars. A tube of 15 gram contains enough silicone gel to treat 3-4 inches (7.5-10 cm) scar twice a day for over 90 days.

   Materials and Methods Top

The study enrolled 30 patients having scars. Written informed consent was taken from all the patients before the study. Also, prior approval of hospital ethical committee was taken before the study. The silicone gel was applied as a thin film twice a day. It was rubbed with fingertips for 2-3 minutes. For fresh scars, treatment was started just days after wound closure or after 5-10 days. The scars were evaluated at monthly intervals. The appearance of scar, including scar type, scar size and scar color was assessed by the physician. We classified hypertrophic scar as a red or dark pink, raised (elevated) sometimes itchy scar confined within the border of the original surgical incision, with spontaneous regression after several months and a generally poor final appearance. A keloid is instead classified as a scar red to brown in colour, very elevated, larger than the wound margins very hard and sometimes painful or pruritic with no spontaneous regression.

Patients were observed and the results were compared at monthly follow up examinations. Follow up was done for 6 months. All scars were measured and photographed before treatment onset. Scars were graded 1 to 4 on the basis of criteria in [Table 1]. Final photographs were taken at this time.

   Results Top

Eleven cases (36.66%) were in the age groups of 30-40 years, 8 (26.66%) cases between 20-30 years, 5 (16.66%) cases between 40-50 years, 2 (6.610%) cases between 10-20 years and 50- 60 years of age each and 1 (3.33%) case of > 60 years of age and between 5 and 10 years of age each. Male:Female ratio was 2:1. It was also seen that most (40%) of the scars were between 1 and 3 months duration, 26.6% of scars were of less than 1 month duration, 20% of scars were between 3 and 6 months and 13.33% scars were of more than 6 months duration. The commonest type of scars were hypertrophic scars (Grade III, 50%) followed by mildly hypertrophic scars (Grade II, 26.6%) and keloids (Grade IV, 23.33%). Most of the scars were between 1 and 3 months duration (40%), 26.6% of scars were of less than 1 month duration, 20% of scars were between 3 and 6 months and 13.33% scars were of more than 6 months duration,

After treatment, improvement was noted in the scars [Figure 1],[Figure 2],[Figure 3]. Sixty percent scars were graded as normal (Grade I), while 20% were graded as mildly hypertrophic (Grade II). Twenty percent of scars were of Grade III and IV at the end of study;10% in each grade [Table 2]. Side effects were few. Allergic reaction to silicone gel was seen in one case and mild desquamation was seen in 2 cases.

   Discussion Top

Since the early 1980s, silicone gel sheeting has been widely used in the treatment of hypertrophic scars and keloids. Several clinical studies and reviews have confirmed its efficacy. [10],[11]

While many treatments have been suggested in the past for scars, only a few of them have been supported by prospective studies with adequate control group. Only two treatments can be said to have sufficient evidence for scar management; topical application of silicone gel sheeting and the intralesional injection of corticosteroids. [12] The former generally is indicated as both a preventive and the therapeutic device, the latter as a therapeutic agent only. [13] Topical silicone gel sheeting is cumbersome to keep on the scar, and the patient compliance often is low for lesions in visible areas. [14],[15],[16] Tapes or bandaging frequently is not accepted. It may also lead to skin irritation, which can require discontinuation of treatment, especially in hot climates. Gel sheeting is effective for scar control, but patient compliance with the method is not always satisfactory. [17],[18],[19] Steroid injections are painful and may lead to skin atrophy and dyschromies. They usually are contraindicated for large areas and for children.

Topical silicon gel application can overcome some of these limitations.

Self drying silicone gel is appealing because it is effective, no fixation is required; it is invisible when dry; and sun blocks, makeup or both can be applied in combination.

However, on areas of the body covered by clothes, it must be perfectly dry before the patient dresses, and this may not be always practical. All the patients felt the gel was easy to apply, but some complained of prolonged drying time. The use of a hair dryer was recommended to overcome this problem. When the scars are located in visible areas, especially on the face, patients can experience psychological discomfort with the visibility of the treatment. In warm climates, skin reactions are relatively common, often leading to treatment interruption. [20],[21]

   Conclusions Top

Topical silicon gel is safe and effective treatment for hypertrophic and keloidal scars. It is easy to apply and cosmetically acceptable.

   References Top

1.Tuan TL, Nichter LS. The molecular basis of keloid and hypertrophic scar formation. Mol Med Today 1998;4:19-24.   Back to cited text no. 1  [PUBMED]  [FULLTEXT]  
2.Dyakov R, Hadjiiski O. Complex treatment and prophylaxis of post-burn cicatrization in childhood. Ann Burns Fire Disasters 2000;13:238-42.   Back to cited text no. 2      
3.Ahn ST. Topical silicone gel: A new treatment for hypertrophic scars. Surgery 1989;106:781-7.   Back to cited text no. 3      
4.Ahn ST. Topical silicone gel for the prevention and treatment of hypertrophic scar. Arch Surg 1991;126:499-504.  Back to cited text no. 4      
5.Beranek JT. Why does topical silicone gel improve hypertrophic scars? A hypothesis. Surgery 1990; 108:12-18.   Back to cited text no. 5      
6.Quinn KJ. Silicone gel in the scar treatment. Burns 1987;13:833-5.  Back to cited text no. 6      
7.Sawada Y, Sone K. Treatment of scars and keloids with a cream containing silicone oil. Br J Plast Surg 1990;43:683-6.  Back to cited text no. 7  [PUBMED]  [FULLTEXT]  
8.Poston J. The use of the silicone gel sheeting in the management of hypertrophic and keloids scars. J Wound Care 2000;9:10-2.  Back to cited text no. 8  [PUBMED]  [FULLTEXT]  
9.Suetake T, Sasai S, Zhen YX, Tagami H. Effects of silicone gel sheet on the stratum corneum hydration. Br J Plast Surg 2000;13:157-9.  Back to cited text no. 9      
10.Baum TM, Busuito MJ. Use of glycerine-based gel sheeting in scar management. Adv Wound Care 1998;11:40-3.   Back to cited text no. 10  [PUBMED]  [FULLTEXT]  
11.Niessen FB. The use of silicone occlusive sheeting (Sil-K) and silicone occlusive gel (Epiderm) in the prevention of hypertrophic scar formation. Plast Reconstr Surg 1998;102:1962-72.   Back to cited text no. 11      
12.Mustoe TA, Cooter RD, Gold MH, Hobbs FD, Ramelet AA, Shakespeare PG, et al. International clinical recommendations on scar management. Plast Reconstruc Surg 2002;110:560-3.  Back to cited text no. 12      
13.Berman B, Flores F. Comparison of a silicone gel filled cushion and silicone gel sheeting for the treatment of hypertrophic or keloid scars. Dermatol Surg 1999;25:484-90.  Back to cited text no. 13  [PUBMED]  [FULLTEXT]  
14.Carney SA, Cason CG, Gowar JP. Cica care gel sheeting in the management of hypertrophic scarring. Burns 1994;20:163-7.  Back to cited text no. 14      
15.Perkins K, Davey RB, Wallis KS. Silicone gel: A new treatment for burn scars contractures. Burns Incl Therm Inj 1983;9:201-6.  Back to cited text no. 15      
16.Mercer NS. Silicone gel in the treatment of keloid scars. Br J Plast Surg 1989;42:83-8.  Back to cited text no. 16  [PUBMED]  [FULLTEXT]  
17.Dockery GL. Treatment of hypertrophic and keloid scars with silastic gel sheeting. J Foot Ankle Surg 1994;33:110-9.   Back to cited text no. 17      
18.Cruz-Korchin NI. Effectiveness of silicone sheets in the prevention of hypertrophic breast scars. Ann Plast Surg 1996;37:345-8.   Back to cited text no. 18  [PUBMED]  [FULLTEXT]  
19.Gibbons M, Zuker R, Brown M, Candlish S, Snider L, Zimmer P. Experience with silastic gel sheeting in pediatric scarring. J Burn Care Rehabil 1994;15:69-73.   Back to cited text no. 19  [PUBMED]  [FULLTEXT]  
20.Borgognoni L, Martini L, Chiarugi C, Gelli R, Reali UM. Hypertrophic scars and keloids: Immunophenotypic features and silicone sheets to prevent recurrences. Ann Burns Fire Disasters 2000;8:164-6.  Back to cited text no. 20      
21.Nikkonen MM, Pitkanen JM, Al Qattan MM. Problems associated with the use of silicone gel sheeting for hypertrophic scars in the hot climate of Saudi Arabia. Burns 2001;27:498-500.  Back to cited text no. 21      

Correspondence Address:
Neerja Puri
C/O Dr. Asha Puri, House No. 626, Urban Estate, Dugri Road, Ludhiana, Punjab
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-2077.58527

Rights and Permissions


  [Figure 1], [Figure 2], [Figure 3]

  [Table 1], [Table 2]

This article has been cited by
1 Mesenchymal stem cell therapy in hypertrophic and keloid scars
Christine Bojanic, Kendrick To, Adam Hatoum, Jessie Shea, K. T. Matthew Seah, Wasim Khan, Charles M. Malata
Cell and Tissue Research. 2021; 383(3): 915
[Pubmed] | [DOI]
2 Bacteriostatic Polylactic Acid Coatings Enriched with Zinc Oxide and Silica Nanoparticles for Titanium Pedicle Screws
Didem Sen Karaman, Mehmet Baran Karakaplan, Nursu Erdogan
JOM. 2021;
[Pubmed] | [DOI]
3 Drug delivery to optimize angiogenesis imbalance in keloid: A review
Aishwari.S. Kumar, Kaladhar Kamalasanan
Journal of Controlled Release. 2021; 329: 1066
[Pubmed] | [DOI]
4 Scars: questions of prevention and treatment
Denis V. Zaslavsky, Anna N. Barinova, Akmal A. Sidikov, Boris M. Tayts, Svyatoslav L. Plavinskij, Darya V. Kozlova, Oksana V. Bulina
Vestnik dermatologii i venerologii. 2021; 97(1): 54
[Pubmed] | [DOI]
5 Surgical scar revision using silicone gel sheet as an adjunct
Tripti Mukherjee, Sumit Chopra, Ankit Aggarwal, Vipul Garg, Himani Dadwal, Priyanka Sharma
National Journal of Maxillofacial Surgery. 2021; 12(1): 36
[Pubmed] | [DOI]
6 Keloids: Current and emerging therapies
Nkemcho Ojeh, Ambadasu Bharatha, Uma Gaur, Andrew LeRoy Forde
Scars, Burns & Healing. 2020; 6: 2059513120
[Pubmed] | [DOI]
7 Hypertrophic scars and keloids: a review and current treatment modalities
Sanjeev Tripathi, Kumud Soni, Poornima Agrawal, Vishal Gour, Rajesh Mondal, Vandana Soni
Biomedical Dermatology. 2020; 4(1)
[Pubmed] | [DOI]
8 Value of silicone gel in prevention of cobblestoning following punch minigrafting in vitiligo
Tag Anbar, Talal Abd El Raheem, Dalia Ahmed Bassiouny, Marwa Mohamed Fawzy, Zeinab El Maadawi, Noha Farouk, Mohamed Hassan
Journal of Dermatological Treatment. 2020; : 1
[Pubmed] | [DOI]
9 Summary and evidence grading of over-the-counter scar treatments
Konstantin V. Grigoryan, Jeremy T. Kampp
International Journal of Dermatology. 2020; 59(9): 1136
[Pubmed] | [DOI]
10 A Prospective Randomized Double-blind study of silicone gel plus Herbal Extracts Versus Placebo in Pre-sternal hypertrophic scar prevention and amelioration
Palakorn Surakunprapha, Kengkart Winaikosol, Bowornsilp Chowchuen, Puttama Punyavong, Kriangsak Jenwitheesuk, Kamonwan Jenwitheesuk
Heliyon. 2020; 6(5): e03883
[Pubmed] | [DOI]
11 Iontophoretic Drug Delivery for the Treatment of Scars
Prashanth Manda,Muralikrishnan Angamuthu,Shobharani R. Hiremath,Vijayasankar Raman,S. Narasimha Murthy
Journal of Pharmaceutical Sciences. 2014; : n/a
[Pubmed] | [DOI]
12 Efficacy and Safety of an Advanced Formula Silicone Gel for Prevention of Post-Operative Scars
Bikash Medhi,Rakesh Kumar Sewal,Lileswar Kaman,Ganesh Kadhe,Amey Mane
Dermatology and Therapy. 2013;
[Pubmed] | [DOI]
13 Comparative effect of topical silicone gel and topical tretinoin cream for the prevention of hypertrophic scar and keloid formation and the improvement of scars
S.Y. Kwon,S.D. Park,K. Park
Journal of the European Academy of Dermatology and Venereology. 2013; : n/a
[Pubmed] | [DOI]
14 Queloides y terapia con silicona. Síntesis de la evidencia disponible
Ariel Hasson,Cristián Navarrete-Dechent,Javier Montoya
Piel. 2012; 27(3): 127
[Pubmed] | [DOI]
15 Management of Acne Scarring, Part II
Lauren L. Levy,Joshua A. Zeichner
American Journal of Clinical Dermatology. 2012; 13(5): 331
[Pubmed] | [DOI]


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
    Email Alert *
    Add to My List *
* Registration required (free)  

    Materials and Me...
    Article Figures
    Article Tables

 Article Access Statistics
    PDF Downloaded1071    
    Comments [Add]    
    Cited by others 15    

Recommend this journal