Journal of Cutaneous and Aesthetic Surgery

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 9  |  Issue : 3  |  Page : 165--171

Stem cell markers (cytokeratin 17 and cytokeratin 19) in scarring and nonscarring alopecia


Dalia El Sakka1, Mohamed Abdel Wahed Gaber2, Asmaa Gaber Abdou3, Moshira Abdel Wahed3, Ahmed Abdel-Wahab Saleh4, Walla Shehata2 
1 Department of Plastic Surgery, Faculty of Medicine, Menoufia University, Shebein Elkom, Egypt
2 Department of Dermatology, Faculty of Medicine, Menoufia University, Shebein Elkom, Egypt
3 Department of Pathology, Faculty of Medicine, Menoufia University, Shebein Elkom, Egypt
4 Department of Dermatology, Benha University, Banha, Egypt

Correspondence Address:
Dr Asmaa Gaber Abdou
Department of Pathology, Faculty of Medicine, Menoufia University, Shebein Elkom
Egypt

Background: Alopecia is one of the most important hair follicle (HF) disorders, which is divided into scarring (cicatricial) and nonscarring (noncicatricial) types. Objective: The aim of this study is to investigate the expression of stem cell (SC) markers such as cytokeratin (CK) 17 and CK19 in scarring and nonscarring alopecia. Materials and Methods: Thirty patients with scalp alopecia (15 with scarring alopecia and 15 without) together with ten healthy volunteers were included in this study. Biopsies were taken from all participants and stained for CK17 and CK19 using immunohistochemistry. Results: There was a statistically significant difference between the nonscarring group and the control group with regard to CK17 expression in the outer layers of the HFs (P = 0.00) and CK19 staining of the inner layers of the HFs (P = 0.008). There was a statistically significant difference between the scarring and the control groups regarding CK17 expression in the outer (P = 0.00) and the inner layers (P = 0.00) of the HFs and CK19 expression in the inner layers of the HFs (P = 0.00). CK17 expression in the outer layers (P = 0.02) and the inner layers of the HFs (P = 0.00) together with CK19 expression in the inner layers of the HFs (P = 0.00) showed statistically significant differences between scarring and nonscarring alopecia groups. Conclusions: The presence of SC markers (CK17 and CK19) in the HFs was affected in both scarring and nonscarring alopecia, but the defect in scarring alopecia is more evident than that of nonscarring alopecia. The persistence of SC markers in some types of scarring alopecia could give a hope for the recovery of these lesions. Further studies are recommended to clarify the benefit from using HF SCs in the treatment of alopecia.


How to cite this article:
El Sakka D, Gaber MA, Abdou AG, Wahed MA, Saleh AA, Shehata W. Stem cell markers (cytokeratin 17 and cytokeratin 19) in scarring and nonscarring alopecia.J Cutan Aesthet Surg 2016;9:165-171


How to cite this URL:
El Sakka D, Gaber MA, Abdou AG, Wahed MA, Saleh AA, Shehata W. Stem cell markers (cytokeratin 17 and cytokeratin 19) in scarring and nonscarring alopecia. J Cutan Aesthet Surg [serial online] 2016 [cited 2019 Dec 14 ];9:165-171
Available from: http://www.jcasonline.com/article.asp?issn=0974-2077;year=2016;volume=9;issue=3;spage=165;epage=171;aulast=El;type=0