Journal of Cutaneous and Aesthetic Surgery
Print this page
Email this page
Small font size
Default font size
Increase font size
Home About us Current issue Archives Instructions Submission Subscribe Editorial Board Partners Contact e-Alerts Login 
Year : 2019  |  Volume : 12  |  Issue : 1  |  Page : 42-48

Correlation between clinical features, biochemical parameters, and histopathological findings in women with patterned baldness: Study from North India

1 Department of Dermatology, Venereology and Leposy. Dr Ram Manohar Lohia Hospital and PGIMER, New Delhi, India
2 Department of Pathology, Dr Ram Manohar Lohia Hospital and PGIMER, New Delhi, India
3 Department of Radiology, Dr Ram Manohar Lohia Hospital and PGIMER, New Delhi, India
4 Department of Biochemistry, Dr Ram Manohar Lohia Hospital and PGIMER, New Delhi, India

Correspondence Address:
Ram Krishan Gautam
Professor and Head Department of Dermatology, Venereology and Leprosy, Dr RML Hospital and PGIMER New Delhi
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JCAS.JCAS_30_18

Rights and Permissions

Background: Androgenetic alopecia (AGA) is a non-scarring alopecia with a characteristic pattern in genetically predisposed men and women. Hormonal abnormalities namely hyperandrogenism, hair cycle defects, genetic predisposition, and follicular miniaturization have been implicated as the causative factors for AGA. Aim: To analyze women with patterned hair loss and correlate their clinical findings with the histopathology and biochemical parameters. Materials and Methods: Female patients between 18 and 45 years of age with a history of hair loss on the crown, temporal area, and recession of hairline were clinically examined. These patients were then subjected to histopathological examination, and on confirmation of diagnosis of female pattern hair loss (FPHL), they were included in the study. Their morning blood sample was taken on 3rd–5th day of the menstrual cycle for hormonal analysis. The study was carried out on 30 patients and 30 age- and sex-matched controls. Results: A statistically significant difference was observed between the mean values of dehydroepiandrosterone sulfate, prolactin, androstenedione, and free triiodothyronine of cases and controls. The most common histopathological finding in our study was an increase in the percentage of telogen hair. Conclusion: The biochemical findings in our study corroborate the role of hyperandrogenism as one of the major etiological factors in FPHL with the role of adrenal androgens being central, and therefore all female patients with FPHL should be evaluated for underlying hormonal imbalances. The role of histopathology in FPHL can be used as a prognostic marker.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded69    
    Comments [Add]    

Recommend this journal