Journal of Cutaneous and Aesthetic Surgery
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Year : 2018  |  Volume : 11  |  Issue : 4  |  Page : 241-244

Capecitabine-induced bilateral ectropion: A rare ocular manifestation requiring surgical intervention

1 Department of Plastic Reconstructive and Aesthetic Surgery, Koç University School of Medicine, Istanbul/, Turkey
2 Department of Ophtalmology, Koç University School of Medicine, Istanbul/, Turkey

Correspondence Address:
Sedat Tatar
Koç Üniversitesi Hastanesi, Davutpaşa caddesi, No:4 Topkapı 34010 Istanbul/Turkey. T: +908522508250, M: +905055039521, F: +902123113410.
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JCAS.JCAS_5_18

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It has been established that many chemotherapeutic agents are associated with a variety of ocular side effects. As an antineoplastic agent, 5-fluorouracil (5-FU) is the chemotherapeutic agent that is frequently linked with cicatricial ectropion. Capecitabine is a prodrug of 5-FU and has a more favorable side effect profile than 5-FU. Frequent side effects of capecitabine include gastrointestinal events and hand–foot–mouth syndrome; cicatricial ectropion is rather uncommon. Enzyme deficiencies affecting the capecitabine metabolism have been reported to be associated with exaggerated generalized systemic and cutaneous side effects; however, there are no cases in the literature reporting capecitabine-induced isolated bilateral-progressive ectropion. Although cessation of the agent is frequently sufficient for the treatment of ectropion, close follow-up is indicated in such patients as permanent damage may occur if the problem is left untreated. We report a case of capecitabine-induced bilateral cicatricial ectropion refractory to treatment cessation, ultimately requiring surgical treatment.

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