Journal of Cutaneous and Aesthetic Surgery
Print this page
Email this page
Small font size
Default font size
Increase font size
Home About us Current issue Archives Instructions Submission Subscribe Editorial Board Partners Contact e-Alerts Login 
RESEARCH ARTICLE
Year : 2013  |  Volume : 6  |  Issue : 2  |  Page : 90-92

Depletion of CD200+ hair follicle stem cells in human prematurely gray hair follicles


1 Department of CTVS, Stem Cell Facility, All India Institute of Medical Sciences, New Delhi, India
2 Department Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Somesh Gupta
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi - 110 029
India
Login to access the Email id

Source of Support: This work was supported by the Indian Association of Dermatologists Venereologists and Leprologists-L'Oreal Pigmentation Research Grant, Conflict of Interest: None


DOI: 10.4103/0974-2077.112669

Rights and Permissions

Introduction: Melanocyte stem cells (MelSCs) are known to be depleted in gray hair follicles. Hair follicle stem cells (HFSCs) are important for maintenance of stemness of MelSCs. Methods: We compared the proportion of CD200+ (Cluster of Differentiation 200 positive) stem cells in the outer root sheath cell suspension of gray and pigmented hair follicles of three patients with the premature graying of hair. In addition, explants culture for HFSCs was also carried out from gray and pigmented hair follicles. Cultured HFSCs were also differentiated into melanocytes. Results: The mean ± SD CD200+ HFSCs population were 9.4 ± 1.4% and 3.5 ± 0.5% for pigmented and gray hair follicles, respectively ( P = 0.002). In explants culture, the growth of HFSCs from the gray hair follicle stopped at around day 20-22, whereas the growth of the cells from the pigmented follicle continued. Conclusion: CD200+ HFSCs are depleted in prematurely gray hair in the humans. CD200+ hair follicle stem cell yield is poorer in gray hair explant culture than pigmented hair explant culture.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2262    
    Printed64    
    Emailed0    
    PDF Downloaded177    
    Comments [Add]    

Recommend this journal