Journal of Cutaneous and Aesthetic Surgery
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   Table of Contents     
EDITORIAL  
Year : 2012  |  Volume : 5  |  Issue : 1  |  Page : 1-2
The value of Mohs surgery for the treatment of nonmelanoma skin cancers


Mohs Surgery Unit, Assuta Medical Center, Tel-Aviv, Israel

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Date of Web Publication27-Mar-2012
 

How to cite this article:
Alcalay J. The value of Mohs surgery for the treatment of nonmelanoma skin cancers. J Cutan Aesthet Surg 2012;5:1-2

How to cite this URL:
Alcalay J. The value of Mohs surgery for the treatment of nonmelanoma skin cancers. J Cutan Aesthet Surg [serial online] 2012 [cited 2014 Jul 22];5:1-2. Available from: http://www.jcasonline.com/text.asp?2012/5/1/1/94322


"Better health with the best cosmetic result." No one can ask more from a surgical procedure in the 21 st century. This phrase best describes Mohs surgery. Mohs micrographic surgery (MMS) has been used as a surgical method for treating skin cancers for the last 70 years. The method has gained popularity among American dermatologists over the past 40 years and worldwide for almost 25 years. Variations of MMS started appearing and indications for surgery also expanded. Initially, MMS was mainly indicated for basal and squamous cell carcinomas (SCCs), i.e. nonmelanoma skin cancers (NMSC). Today, the method is applicable for a variety of other skin cancers such as melanoma in situ, microcystic adnexal carcinoma, dermatofibrosarcoma protuberans and other adnexal and spindle cell tumours. The essentials of MMS were published by the American College of Mohs Surgery in 1988, [1] and in 1994 the American Academy of Dermatology published a position paper on the guidelines of MMS. [2] This surgical method has been developed and performed by dermatologists, and most of the articles published in peer-reviewed journals were written by dermatologists. The value of MMS for the treatment of NMSC has been well established in the literature. The primary tumour indication for MMS is NMSC. In a survey conducted among American Mohs surgeons, 98% of the tumours treated by MMS were NMSC. [3] Seventy-three percent of the tumours were basal cell carcinomas (BCCs) and 23% were SCCs. An important contribution of MMS to the treatment of BCC is its ability to significantly reduce tumour recurrence.

During the early years of use of MMS, mainly large, recurrent BCCs were treated. In recent years, referral patterns have changed towards a preference for Mohs surgery for the treatment of smaller, primary BCCs. This may be a result of increased awareness by the dermatologic and medical community of the numerous advantages of Mohs surgery. Furthermore, there is a greater appreciation of MMS tissue-sparing properties, which may result in less complex and more successful aesthetic reconstructions. [4] Low recurrence rates are achieved by MMS in BCC treatment. Three recent studies from Europe examined the recurrence rate of BCC after MMS. In a recent study performed in Italy, the BCC recurrence rate after MMS was 3.4% for primary BCC and 4.9% for recurrent BCC. [5] A study from Sweden showed that the resulting 5-year recurrence rates were 2.1% for primary (previously untreated) tumours, 5.2% for recurrent BCCs and 3.3% overall. In total, 87.9% of the tumours required at least two stages of Mohs micrographic surgery. [6] A study from Spain showed that over a mean follow-up period of 32 months, the recurrence rate was 0.37%. [7] Mohs surgery is performed today on all types of BCCs including the superficial type. SCC is a more aggressive type of NMSC than BCC. Its relationship to cumulative sun exposure is well known and it is much more frequent in organ transplant patients. Due to the unique characteristics of MMS, it is used for the treatment of primary and recurrent SCC. A recent study showed that the recurrence rate of SCC after MMS is as low as 1.2%. [8] MMS is also indicated for SCC of the penis, nail unit and extremities in organ transplant patients. Mohs surgery is able to track SCC with perineural invasion and in transit metastases of SCC. Nowadays, we know that massive inflammatory infiltrate in SCC can mask tumour persistence. Hence, in current practice, we remove extra layers in MMS when we see this type of infiltrate. Although MMS is the gold standard for the treatment of NMSC, we must use the method wisely and according to the proper indications. In the author's opinion, there is no rationale for performing MMS on a primary BCC on the extremities or the trunk. Expanding the use of this method for inappropriate indications raises the cost of medical expenses in certain societies.

In conclusion, based on my personal experience in MMS for almost 20 years, I prefer to define Mohs surgery in a rigid functional way: Peripheral margins must be cut at an angle of 45° in most cases; frozen sections are by definition part of modern MMS; the frozen section laboratory must be adjacent to the operating room; and the surgeon should be the one who reads the slides. If all of these criteria are not met, the surgical method should neither be called Mohs surgery nor should the word "Mohs" be part of its name. I would like to add more points in favour of Mohs surgery as addressed by McGovern and Leffel: [9] "Unifying the duties of surgeon and pathologist assures fewer errors when performing histopathologic and clinical correlation for each patient. Separating the tasks between two physicians increases the errors in mapping and applying the Mohs map to subsequent stages." However, I am strongly in favour of seeking a quality assurance via interaction with a dermatopathologist.

 
   References Top

1.Cottel WI, Bailin PL, Albom MJ, Bernstien G, Braun M, Hanke CW, et al. Essentials of Mohs micrographic surgery. J Dermatol Surg Oncol 1988;14:11-3.  Back to cited text no. 1
    
2.Drake LA, Dinehart SM, Goltz RW, Graham GF, Hordinsky MK, Lewis CW, et al. Guidelines of care for Mohs micrographic surgery. American academy of dermatology. J Am Acad Dermatol 1995;33:271-8.  Back to cited text no. 2
[PUBMED]    
3.Campbell RM, Perlis CS, Malik MK, Dufresne RG Jr. Characteristics of Mohs practice in the United States: A recall survey of ACMS surgeons. Dermatol Surg 2007;33:1413-8.  Back to cited text no. 3
[PUBMED]  [FULLTEXT]  
4.Kaplan AL, Weitzul SB, Taylor RS. Longitudinal diminution of tumor size for basal cell carcinoma suggests shifting referral patterns for Mohs surgery. Dermatol Surg 2008;34:15-9.  Back to cited text no. 4
[PUBMED]  [FULLTEXT]  
5.Veronese F, Farinelli P, Zavattaro E, Zuccoli R, Bonvini D, Leigheb G, et al. Basal cell carcinoma of the head region: Therapeutical results of 350 lesions treated with Mohs micrographic surgery. J Eur Acad Dermatol Venereol 2011;10:1468-3083.  Back to cited text no. 5
    
6.Paoli J, Daryoni S, Wennberg AM, Mölne L, Gillstedt M, Miocic M, et al. 5-year recurrence rates of Mohs micrographic surgery for aggressive and recurrent facial basal cell carcinoma. Acta Derm Venereol 2011;91:689-93  Back to cited text no. 6
    
7.Galimberti G, Pontón Montaño A, Ferrario D, Kowalczuk A, Galimberti R. Mohs micrographic surgery for the treatment of basal cell carcinoma. Actas Dermosifiliogr 2010;101:853-7.  Back to cited text no. 7
    
8.Pugaliano-Mauro M, Goldman G. Mohs surgery is effective for high risk cutaneous squamous cell carcinoma. Dermatol Surg 2010;36:1544-155.  Back to cited text no. 8
    
9.McGovern TW, Leffel DJ. Mohs surgery. The informed view. Arch Dermatol 1999;135:1255-9.  Back to cited text no. 9
    

 
   Authors Top



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Correspondence Address:
Joseph Alcalay
SMC 26 Habarzel Street, Tel-Aviv, 69710
Israel
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DOI: 10.4103/0974-2077.94322

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