Journal of Cutaneous and Aesthetic Surgery
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   Table of Contents     
ORIGINAL ARTICLE  
Year : 2011  |  Volume : 4  |  Issue : 3  |  Page : 197-200
Cutaneous horns in an African population


1 Department of Orthopaedics and Traumatology, Division of Plastic Surgery, College of Medical Sciences, University of Benin, Benin City, Nigeria
2 Department of Morbid Anatomy, College of Medical Sciences, University of Benin, Benin City, Nigeria

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Date of Web Publication28-Dec-2011
 

   Abstract 

Background : Cutaneous horns are hard, yellowish gray cornified skin growths. They are more common in white races and believed to be rare in Africans. There are few case reports of the lesion in African populations in the English literature. Materials and Methods : This report documents six patients with this lesion seen over a fourteen month period. There were three males and three females, aged 22 to 62 (mean= 47). Results : One lesion was on the scalp, the remaining on the extremities. The underlying pathologies were squamous cell carcinoma (1), Kaposi sarcoma (1), cutaneous myxoma (1), eccrine poroma (1) and the remaining two showed only chronic inflammatory changes with subepidermal lymphocytic and macrophage cell infiltrates. Conclusion : Unless cases are well documented, the perception of rarity in Africans will most likely persist. The risk of underling malignancy underscores the need for detailed evaluation and prompt management.

Keywords: Cornu cutaneum, cutaneous horns, horns, squamous cell carcinoma

How to cite this article:
Oludiran OO, Ekanem VJ. Cutaneous horns in an African population. J Cutan Aesthet Surg 2011;4:197-200

How to cite this URL:
Oludiran OO, Ekanem VJ. Cutaneous horns in an African population. J Cutan Aesthet Surg [serial online] 2011 [cited 2019 Aug 17];4:197-200. Available from: http://www.jcasonline.com/text.asp?2011/4/3/197/91253



   Introduction Top


Cutaneous horns are cornified skin growths shaped in the form of a horn. However, they differ from true animal horns in not having a bony core. [1],[2],[3] They vary in shape and sizes. Like other noninfective skin lesions, they are common in the Caucasian and Asian races but reportedly rare in people of African descent. [4] This racial predilection can be attributed to the relative protection the pigmented skin enjoys from ultraviolet sun rays. This also correlates with the racial distribution of other skin lesions that are related to actinic damage. The relative anatomic distribution of the lesions similarly is also remarkably related to the relative exposure of different parts of the human body to sun rays. Over 30% of these lesions are seen in the head and neck region. [3],[4]

The earliest report of 1558 describes a commercial exhibition of the photograph of a patient with this morphologic entity as a curious anomaly of nature. [5],[6] Several documentations have appeared thereafter detailing its clinical appearances and pathobiology, including the possible risk of underlying malignancy, in the English literature. However, there is relative paucity of information on this entity in Africans. The first documentation from Africa was of an Arab and was related to a previous scalp burn. [4] While probably not as rare in blacks as thought, the only case reported so far from Nigeria, in the English literature, was of a female farmer who had this lesion on the sole of the foot and was related to a cutaneous myxoma. [7] Since then, five additional cases have presented to the author in the plastic surgery services of the University of Benin Teaching Hospital, Benin City. These form the basis of this report, to draw attention to a probably neglected entity. It would appear they are not as rare as previously thought. A brief review of the literature is undertaken to familiarize medical practitioners with this pathologic entity. It is pertinent also for surgeons in the region, and in general, to be aware of the possibility of some underlying malignancy so as not to treat it as being innocuous.


   Materials and Methods Top


Six patients managed by the author at the Burns, Plastic and Reconstructive Surgery Unit, University of Benin Teaching Hospital, Benin City, Nigeria, form the basis of this report. The patients were seen from January 2010 to February 2011. A record was made of the patient demographic data, race and skin type, the site of the lesions, duration of symptoms, prior treatment if any, and the histopathology of the base of the lesion. Diagnosis was clinical in all cases. Basic investigations carried out were patients' hematocrit and blood sugar levels. All excisions were done under local anesthesia using 1% lidocaine with adrenaline except in the digits where plain lidocaine was employed. Where a split thickness skin graft was needed, this was taken with a field block. The defects were closed either directly or with a split thickness skin graft depending on the size of the base of the lesion and laxity of the surrounding tissue. All the specimens were examined histopathologically. All but the last patient have been followed up for over 6 months.


   Results Top


There were six patients, three males and three females giving a sex ratio of 1:1. The age ranged between 22 and 62 years, with a mean of 47. Two patients were in their 20s, and the remaining four were over 50 years. All the patients were Nigerians. None was an albino. The lesion was on the scalp in a male patient aged 62 years [Figure 1]. The remaining five lesions were located on the extremity: lower limb (3), upper limb (2). The scalp lesion had underlying squamous cell carcinoma [Figure 2], while the toe lesion had a background of Kaposi sarcoma [Figure 3] and [Figure 4]. Others were cutaneous myxoma (1), eccrine poroma (1) [Figure 5], and 2 showing only chronic inflammatory changes. No adjuvant therapy was given. There has been no recurrence.
Figure 1: Cutaneous horn on the scalp of a 62-year-old man. The base of the lesion was a squamous cell carcinoma

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Figure 2: Cutaneous horn showing hyperkeratosis, parakeratosis, prominent rete pegs, and prominent mitotic figures with dermal invasion

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Figure 3: Yellowish gray horn arising from the eponychium of the big toe

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Figure 4: Kaposi sarcoma: Malignant neoplastic lesions with spindle shaped cells infiltrate in the dermis separated by slit like spaces filled with red blood cells

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Figure 5: Eccrine poroma: Section of the skin showing a lesion composed of relatively uniform basaloid cells that are arranged in nodules and columns extending from the epidermis to the dermis

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   Discussion Top


The clinical diagnosis of cutaneous horns is simple, based only on the morphologic resemblance to an animal horn. In all the cases, the diagnosis was made at first contact. Mc Grouther [6] provides an excellent illustration of a sebaceous horn of the scalp which should be familiar to medical students and practitioners alike. He however described this as desiccated secretions from the orifice of a sebaceous cyst. This is not always the case. Neither are these horns always of sebaceous origin. Rather, they are highly keratinized concretions which protrude above the surface of the skin. [8] They are also not always horn shaped. The lesion may also be flat, nodular, or crateriform although attempts have been made to define it as a compact mass of keratin whose base height is at least half of the base diameter. [8],[9],[10] This is evident in the scalp lesion illustrated here.

Although the series are few in number, it is evident that unlike in the Caucasians, younger patients are not exempt from this uncommon pathology. Two were in their 20s. While repeated trauma may be adduced as plausible etiological factor for the male with a foot lesion, the same may not be so easily accepted by the lady with a lesion on the forearm. However, her lesion was located at a site subject to friction in normal life, being just proximal to the extensor surface of the elbow [Figure 6]. Repeated trauma as a strong etiological factor in our series may be alluded to further given the fact that all lesions but one are located in the extremities, mostly at sites so exposed.
Figure 6: Horn on the extensor surface of the forearm

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Beyond the curiosity is the more serious fact that the lesion may sit atop a malignant base. [1],[3],[6],[8] In this series, two were malignant (33%). This is often not detected clinically. Thus, it is essential to subject the lesions to histology after adequate excision. Certain risk factors for malignancy have been elucidated. These include a large size, a wide base relative to height, tenderness at the base, advanced age, and the male sex. [11] The two lesions showing malignant features occurred in males and had relatively broad bases. However, no clinical feature(s) reliably discriminates benign from malignant lesions. Half of the lesions are said to be benign, about a quarter premalignant (actinic keratosis), and 20-25% malignant. [1],[11],[12] This is however reported in a series of Caucasians. Until a large series of Africans is studied, the exact proportions in this race remain uncertain. Mantese et al. [3] in their series of 211 patients characterized 33 as nonwhites. Eighteen (54.55%) of these had premalignant lesions, 12 (36.36%) were benign, and only 3 patients (9.09%) had a malignant base pathology. Other premalignant and malignant diseases associated with cutaneous horns include actinic keratosis, basal cell carcinoma, malignant melanoma, Kaposi's sarcoma, Bowen's disease, Paget's disease, sebaceous carcinoma, and a case of metastatic renal cell carcinoma. [6],[13],[14],[15]

In four of our patients, the base pathology did not show any evidence of malignancy. This is a common trend in most series. Cutaneous horns have been associated with several more common benign lesions such as angiokeratoma, angioma, benign lichenoid sclerosis, dermatofibroma, discoid lupus, epidermal nevus, keratoacanthoma, granular cell tumor, pyogenic granuloma, sebaceous adenoma, seborrheic keratosis, trichilemmoma, cutaneous myxoma, inverted follicular keratosis, and infective skin conditions like the verruca vulgaris, pyogenic grannuloma, molluscum contagiosum of the pox virus, and cutaneous leishmaniasis. [6],[7],[13],[14] Although no histologic description of a specific infective condition was reported in any of our patients, there were descriptions of subepidermal chronic inflammatory infiltrates mainly of lymphocytes and macrophages in two. This however does not necessarily imply an infective origin. In the fifth patient, the base lesion was a cutaneous myxoma and the other was an eccrine poroma [Figure 5].

In our series, the treatment modality is surgical excision with macroscopic free margins and histopathology of the lesion. This is often adequate being diagnostic and therapeutic and remains the treatment of choice. [6] The surgical defects were usually amenable to direct closure or resurfacing with skin grafts. In the patient with squamous cell carcinoma, the excision margins were free of tumors and regional nodes were not clinically involved. He is still on follow-up in the outpatient clinic. An inadequate margin should prompt further excision. A search should also be made for local or distant spread. Where facility is available for frozen section histology, shave excision has been employed with satisfactory results. This becomes invaluable when the lesion is present on cosmetically sensitive part of the body like the medial canthus of the eyelid. Other modalities such as electrodessication, laser ablation, and cryosurgery have also been described. [16] This may suffice for benign lesions. Valuable information on the margins may be lost with these alternatives.


   Conclusion Top


Cutaneous horns are probably neglected and are not rare as thought. The propensity for malignancy at the base also exists in blacks and should be sought when the horns are seen. In the face of scarce resources, excision biopsy is adequate. Health care givers should refer cases to the surgical service as soon as possible. The surgeon should also search for evidence of spread when malignancy is detected. Furthermore, follow-up should be adequate for which a period of 3 years has been suggested.

 
   References Top

1.Mencia-Gutierrez E, Gutierrez-Diaz E, Redondo-Marcus I, Ricoy JR, Garcia-Torre JP. Cutaneous horn of the eyelid; a clinicalpathological study of 48 cases. J Cutan Pathol 2004;31:539-43.  Back to cited text no. 1
    
2.Souza LN, Martins CR, de Paula AM. Cutaneous horn occurring on the lip of a child. Int J Paediatr Dent 2003;13:365-7.  Back to cited text no. 2
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3.Mantese SAO, Diago PM, Rocha A, Berbert AL, Ferreira AK, Ferreira TC. Cutaneous Horn: A retrospective histopatholgical study of 222 cases. An Bras Dermatl 2010;85:157-63.  Back to cited text no. 3
    
4.Nthuuta PM. Gant cutaneous horn in an African woman - a case report. J Med Case Rep 2007;1:170.  Back to cited text no. 4
    
5.Bondeson J. Everard Hommes, John Hunter, and cutaneous horns: a historical review. Am J Dermatopathol 2001:23;362-9.  Back to cited text no. 5
    
6.Copcu E, Sivrioglu N, Culhaci N. Cutaneous horns: Are those lesions as innocent as they seem to be? World J Surg Oncol 2004;2:18.  Back to cited text no. 6
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7.Oludiran OO, Ekanem VJ, Umebese PF. Plantar cornu cutaneum associated with cutaneous myxoma. Surg Sci 2011;2:13-5.  Back to cited text no. 7
    
8.McGrouther DA. Skin. Burns. In: Mann CV, Russell RC, Willaims NS, editors. Bailey and Love's short practice of surgery. 22 nd ed. 2-6 Boundary Row, London SEI 8HN, UK: Chapman and Hall; 1995. p. 126.  Back to cited text no. 8
    
9.Tauro LF, Martins JJS, John SK, Keinear KP. Cornu cutaneum at an unusual site. Indian J Plast Surg 2006;39:76-8.  Back to cited text no. 9
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10.Bart RS, Andrade R, Kopf AW. Cutaneous horns. A clinical and histopathologic study. Acta Derm Venereol 1968;48:507-15.  Back to cited text no. 10
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11.Yu RC, Pryce DW, Macfarlane AW, Stewart TW. A histopathological study of 643 cutaneous horns. Br J Dermatol 1991;124:449-52.  Back to cited text no. 11
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12.Schosser RH, Hodge SJ, Gaba CR, Owen LG. Cutaneous horns: A histopathologic study. South Med J 1979;72:1129-31.  Back to cited text no. 12
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13.Gould JW, Brodell RT. Giant cutaneous horn associated with verucca vulgaris. Cutis 1991;64:111-2.  Back to cited text no. 13
    
14.Findley RF, Lapins NA. Pyogenic grannulorna stimulating a cutaneous horn. Cutis 1983;31:610-12.  Back to cited text no. 14
    
15.Krzystof D. Howards Paget's disease of the breast presenting as a cutaneous horn. J Surg Oncol 2006;29:237-9.  Back to cited text no. 15
    
16.Lowe FC, Mc Cullough AR. Cutaneous horn of the penis- an approach to management. Case report and Review of the literature. J Am Acad Dermatol 1985;13:369-73.  Back to cited text no. 16
    

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Correspondence Address:
Olugbenga O Oludiran
Department of Orthopaedics and Traumatology, Division of Plastic Surgery, College of Medical Sciences, University of Benin, Benin City
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-2077.91253

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    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6]

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